Stem Cell Epigenetics

Stem Cell Epigenetics, Volume 8, examines how epigenetics are involved in stem cell differentiation, how a stem cell rapidly transitions into a molecularly distinct cell type, and how this process may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, epigenetic regulation of reprogramming, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, epigenetics and disease modeling, organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment is discussed in detail, helping researchers and physicians bring this exciting and fast evolving field to the clinic. Provides genetic researchers, students and physicians with evidence indicating the epigenetic mechanisms involved in stem cell differentiationHighlights the specific characteristics of the epigenetic modifications and misregulations that may result in disease pathogenesisExamines the potential application of stem cell epigenetics towards developing therapeutic interventions for disease and advancing regenerative medicineFeatures chapter contributions by leading international experts

Pages: 464

Volume: 17

Edition: 01

Publisher: Academic Press, Incorporated

Copyright: 2020

Published: 08/20

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